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Review
. 2004 Jun;14(3):181-5.
doi: 10.1016/j.semcancer.2003.10.004.

Chemokines in neoplastic progression (VSports手机版)

Albert Zlotnik  1
Affiliations
Review

Chemokines in neoplastic progression (V体育平台登录)

Albert Zlotnik. Semin Cancer Biol. 2004 Jun.

Abstract

Chemokines and their receptors have emerged as attractive targets regulating the migration of tumor cells in vivo, a process known as cancer metastasis. The control of metastasis is critical to the control of cancer progression. Two chemokine receptors and their ligands stand out as likely targets for therapeutics: CCR7/CCL21 for lymph node metastases, and CXCR4/CXCL12 for lung, liver, bone marrow, and brain metastases VSports手机版. The most widely expressed chemokine receptor among cancers is likely to be CXCR4. .

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