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. 2004 Jun 15;64(12):4059-63.
doi: 10.1158/0008-5472.CAN-04-0291.

Deletion of laminin-8 results in increased tumor neovascularization and metastasis in mice (VSports最新版本)

Zhongjun Zhou  1 , Masayuki Doi, Jianming Wang, Renhai Cao, Baohua Liu, Kui Ming Chan, Jarkko Kortesmaa, Lydia Sorokin, Yihai Cao, Karl Tryggvason
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"VSports app下载" Deletion of laminin-8 results in increased tumor neovascularization and metastasis in mice

Zhongjun Zhou et al. Cancer Res. .

Abstract

Laminin-8 (alpha 4 beta 1 gamma 1) is one of the major laminin isoforms expressed in vascular endothelial basement membranes. Here we show that deletion of laminin-8 in mice affects angiogenesis under pathological conditions. Murine tumor models used in laminin alpha 4-deficient mice results in hyperneovascularization and significant promotion of tumor growth and metastasis. The higher tumor growth rates in mutant mice correlate with decreased tumor cell apoptosis. Depletion of laminin alpha 4 chain may alter the structure of vascular basement membranes, leading to increased angiogenesis. Our data suggest that the laminin-8 plays a critical role in the regulation of pathological angiogenesis. VSports手机版.

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