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Review
. 2004;6(3):119-27.
doi: 10.1186/bcr781. Epub 2004 Mar 18.

Phyto-oestrogens and breast cancer chemoprevention

Jane L Limer  1 , Valerie Speirs
Affiliations
Review

Phyto-oestrogens and breast cancer chemoprevention

Jane L Limer et al. Breast Cancer Res. 2004.

"V体育2025版" Abstract

Phytoestrogens are polyphenol compounds of plant origin that exhibit a structural similarity to the mammalian steroid hormone 17beta-oestradiol. In Asian nations the staple consumption of phyto-oestrogen-rich foodstuffs correlates with a reduced incidence of breast cancer. Human dietary intervention trials have noted a direct relationship between phyto-oestrogen ingestion and a favourable hormonal profile associated with decreased breast cancer risk. However, these studies failed to ascertain the precise effect of dietary phyto-oestrogens on the proliferation of mammary tissue. Epidemiological and rodent studies crucially suggest that breast cancer chemoprevention by dietary phyto-oestrogen compounds is dependent on ingestion before puberty, when the mammary gland is relatively immature. Phyto-oestrogen supplements are commercially marketed for use by postmenopausal women as natural and safe alternatives to hormone replacement therapy. Of current concern is the effect of phyto-oestrogen compounds on the growth of pre-existing breast tumours. Data are contradictory, with cell culture studies reporting both the oestrogenic stimulation of oestrogen receptor-positive breast cancer cell lines and the antagonism of tamoxifen activity at physiological phyto-oestrogen concentrations. Conversely, phyto-oestrogen ingestion by rodents is associated with the development of less aggressive breast tumours with reduced metastatic potential. Despite the present ambiguity, current data do suggest a potential benefit from use of phyto-oestrogens in breast cancer chemoprevention and therapy. These aspects are discussed VSports手机版. .

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Figures

Figure 1
Figure 1
Structural comparison of the natural and synthetic oestrogens (a) 17β-oestradiol and (b) diethylstilbestrol with the principal classes of phyto-oestrogen: the stilbene (c) resveratrol, lignan compounds (d) enterolactone and (e)enterodiol, the coumestan (f) coumestrol, and isoflavones (g) genistein, (h) daidzein and (i) biochanin A.
See this image and copyright information in PMC

References

    1. Messina MJ. Legumes and soybeans: overview of their nutritional profiles and health effects. Am J Clin Nutr. 1999;Suppl:439S–450S. - PubMed
    1. Barnes S. Phytoestrogens and cancer. Baillières Clin Endocrinol Metab. 1998;12:559–579. - PubMed
    1. Lamartiniere CA. Protection against breast cancer with genistein: a component of soy. Am J Clin Nutr. 2000;Suppl:1705S–1707S. - PubMed
    1. Dai Q, Shu X-O, Jin F, Potter JD, Kushi LH, Teas J, Gao Y-T, Zheng W. Population-based case-control study of soyfood intake and breast cancer risk in Shanghai. Br J Cancer. 2001;85:372–387. doi: 10.1054/bjoc.2001.1873. - DOI - PMC - PubMed
    1. Wu AH, Ziegler RG, Nomura AMY, West DW, Kolonel LN, Horn-Ross PL, Hoover RN, Pike MC. Soy intake and risk of breast cancer in Asians and Asian Americans. Am J Clin Nutr. 1998;Suppl:1437S–1443S. - PubMed

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