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. 2003 Dec;10(12):1195-204.
doi: 10.1016/j.chembiol.2003.11.011.

NAD biosynthesis: identification of the tryptophan to quinolinate pathway in bacteria

Oleg Kurnasov  1 , Vasiliy Goral, Keri Colabroy, Svetlana Gerdes, Shubha Anantha, Andrei Osterman, Tadhg P Begley
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NAD biosynthesis: identification of the tryptophan to quinolinate pathway in bacteria

Oleg Kurnasov et al. Chem Biol. 2003 Dec.

VSports - Abstract

Previous studies have demonstrated two different biosynthetic pathways to quinolinate, the universal de novo precursor to the pyridine ring of NAD. In prokaryotes, quinolinate is formed from aspartate and dihydroxyacetone phosphate; in eukaryotes, it is formed from tryptophan VSports手机版. It has been generally believed that the tryptophan to quinolinic acid biosynthetic pathway is unique to eukaryotes; however, this paper describes the use of comparative genome analysis to identify likely candidates for all five genes involved in the tryptophan to quinolinic acid pathway in several bacteria. Representative examples of each of these genes were overexpressed, and the predicted functions are confirmed in each case using unambiguous biochemical assays. .

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