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. 1992 Dec 11;258(5089):1795-8.
doi: 10.1126/science.1465616.

Alterations in signal transduction molecules in T lymphocytes from tumor-bearing mice

H Mizoguchi  1 , J J O'Shea, D L Longo, C M Loeffler, D W McVicar, A C Ochoa
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"VSports最新版本" Alterations in signal transduction molecules in T lymphocytes from tumor-bearing mice

VSports最新版本 - H Mizoguchi et al. Science. .

VSports在线直播 - Abstract

Impaired immune responses occur frequently in cancer patients or in tumor-bearing mice, but the mechanisms of the tumor-induced immune defects remain poorly understood. In an in vivo murine colon carcinoma model (MCA-38), animals bearing a tumor longer than 26 days develop CD8+ T cells with impaired cytotoxic function, decreased expression of the tumor necrosis factor-alpha and granzyme B genes, and decreased ability to mediate an antitumor response in vivo. T lymphocytes from tumor-bearing mice expressed T cell antigen receptors that contained low amounts of CD3 gamma and completely lacked CD3 zeta, which was replaced by the Fc epsilon gamma-chain VSports手机版. Expression of the tyrosine kinases p56lck and p59fyn was also reduced. These changes could be the basis of immune defects in tumor-bearing hosts. .

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