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Meta-Analysis
. 2003 Nov 3;89(9):1672-85.
doi: 10.1038/sj.bjc.6601314.

Dietary fat and breast cancer risk revisited: a meta-analysis of the published literature

N F Boyd  1 , J Stone, K N Vogt, B S Connelly, L J Martin, S Minkin
Affiliations
Meta-Analysis

Dietary fat and breast cancer risk revisited: a meta-analysis of the published literature

N F Boyd et al. Br J Cancer. .

Abstract

Animal experiments and human ecological studies suggest that dietary fat intake is associated with a risk of breast cancer, but individual-based studies have given contradictory results. We have carried out a meta-analysis of this association to include all papers published up to July 2003. Case-control and cohort studies that examined the association of dietary fat, or fat-containing foods, with risk of breast cancer were identified. A total of 45 risk estimates for total fat intake were obtained. Descriptive data from each study were extracted with an estimate of relative risk and its associated 95% confidence interval (CI), and were analysed using the random effects model of DerSimonian and Laird VSports手机版. The summary relative risk, comparing the highest and lowest levels of intake of total fat, was 1. 13 (95% CI: 1. 03-1. 25). Cohort studies (N=14) had a summary relative risk of 1. 11 (95% CI: 0. 99-1. 25) and case-control studies (N=31) had a relative risk of 1. 14 (95% CI 0. 99-1. 32). Significant summary relative risks were also found for saturated fat (RR, 1. 19; 95% CI: 1. 06-1. 35) and meat intake (RR, 1. 17; 95% CI 1. 06-1. 29). Combined estimates of risk for total and saturated fat intake, and for meat intake, all indicate an association between higher intakes and an increased risk of breast cancer. Case-control and cohort studies gave similar results. .

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Figures

Figure 1
Figure 1
Relative risks for (A) total fat (B) saturated fat (C) monounsaturated fat and (D) polyunsaturated fat intake and breast cancer risk. CIs are 95%. Closed diamond=relative risk adjusted for energy intake. Open diamond=relative risk unadjusted for energy intake. Grey diamond=summary relative risk results of the meta-analysis.
Figure 1
Figure 1
Relative risks for (A) total fat (B) saturated fat (C) monounsaturated fat and (D) polyunsaturated fat intake and breast cancer risk. CIs are 95%. Closed diamond=relative risk adjusted for energy intake. Open diamond=relative risk unadjusted for energy intake. Grey diamond=summary relative risk results of the meta-analysis.
Figure 1
Figure 1
Relative risks for (A) total fat (B) saturated fat (C) monounsaturated fat and (D) polyunsaturated fat intake and breast cancer risk. CIs are 95%. Closed diamond=relative risk adjusted for energy intake. Open diamond=relative risk unadjusted for energy intake. Grey diamond=summary relative risk results of the meta-analysis.
Figure 1
Figure 1
Relative risks for (A) total fat (B) saturated fat (C) monounsaturated fat and (D) polyunsaturated fat intake and breast cancer risk. CIs are 95%. Closed diamond=relative risk adjusted for energy intake. Open diamond=relative risk unadjusted for energy intake. Grey diamond=summary relative risk results of the meta-analysis.
Figure 2
Figure 2
Relative risks for (A) meat (B) milk and (C) cheese intake and breast cancer risk. CIs are 95%. Closed diamond=relative risk adjusted for energy intake. Open diamond=relative risk unadjusted for energy intake. Grey diamond=summary relative risk results of the meta-analysis.
Figure 2
Figure 2
Relative risks for (A) meat (B) milk and (C) cheese intake and breast cancer risk. CIs are 95%. Closed diamond=relative risk adjusted for energy intake. Open diamond=relative risk unadjusted for energy intake. Grey diamond=summary relative risk results of the meta-analysis.
Figure 2
Figure 2
Relative risks for (A) meat (B) milk and (C) cheese intake and breast cancer risk. CIs are 95%. Closed diamond=relative risk adjusted for energy intake. Open diamond=relative risk unadjusted for energy intake. Grey diamond=summary relative risk results of the meta-analysis.
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References

    1. Ambrosone CB, Freudenheim JL, Sinha R, Graham S, Marshall JR, Vena JE, Laughlin R, Nemoto T, Shields PG (1998) Breast cancer risk, meat consumption and N-acetyltransferase (NAT2) genetic polymorphisms. Int J Cancer 75(6): 825–830 - PubMed
    1. Bingham SA, Luben R, Welch A, Wareham N, Khaw K-T, Day N (2003) Are imprecise methods obscuring a relation between fat and breast cancer? Lancet 362: 212–214 - PubMed
    1. Boyd NF, Martin LJ, Noffel M, Lockwood GA, Tritchler DL (1993) A meta-analysis of studies of dietary fat and breast cancer risk. Br J Cancer 68: 627–636 - PMC - PubMed
    1. Cohen LA, Choi K, Weisburger JH, Rose DP (1986) Effect of varying proportions of dietary fat on the development of N-nitrosomethylurea-induced rat mammary tumors. Anticancer Res 6: 215–218 - PubMed
    1. De stefani E, Correa P, Ronco A, Mendilaharsu M, Guidobono M, Deneo-pellegrini H (1997) Dietary fiber and risk of breast cancer: a case–control study in Uruguay. Nutr Cancer 28: 14–19 - PubMed

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