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Review
. 2003 Aug;4(8):657-65.
doi: 10.1038/nrm1175.

Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis

Stefan Grünert  1 , Martin Jechlinger, Hartmut Beug
Affiliations
Review

"V体育官网入口" Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis

Stefan Grünert et al. Nat Rev Mol Cell Biol. 2003 Aug.

Abstract

In contrast to the aberrant control of proliferation, apoptosis, angiogenesis and lifespan, the cellular mechanisms that cause local invasion and metastasis of tumour cells are still poorly understood. New experimental approaches have identified different types of epithelial-plasticity changes in tumour cells towards fibroblastoid phenotypes as crucial events that occur during metastasis, and many molecules and signalling pathways cooperate to trigger these processes. VSports手机版.

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