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Comparative Study
. 2003 Jan 27;88(2):237-44.
doi: 10.1038/sj.bjc.6600701.

VSports最新版本 - Vascular endothelial growth factor-D is an independent prognostic factor in epithelial ovarian carcinoma

Y Yokoyama  1 , D S Charnock-Jones, D Licence, A Yanaihara, J M Hastings, C M Holland, M Emoto, M Umemoto, T Sakamoto, S Sato, H Mizunuma, S K Smith
Affiliations
Comparative Study

Vascular endothelial growth factor-D is an independent prognostic factor in epithelial ovarian carcinoma

"VSports手机版" Y Yokoyama et al. Br J Cancer. .

Abstract

We assessed the presence of vascular endothelial growth factor (VEGF)-C, VEGF-D and their receptor VEGFR-3 by immunohistochemistry in 59 epithelial ovarian carcinomas, 11 borderline tumours and 20 benign cystadenomas VSports手机版. VEGF-C and VEGF-D were generally expressed in tumour cells and also in endothelia adjacent to tumour nests which showed a strong staining for them. VEGFR-3 was expressed in lymphatic and vascular endothelial cells adjacent to tumour nests. Immunoreactivity was significantly more frequent as lesions progressed from a benign tumour to advanced carcinoma. A strong correlation was found between VEGF-C and VEGF-D detected in carcinoma and VEGFR-3 detected in neighbouring endothelial cells. Increased expression of VEGF-C, VEGF-D and VEGFR-3 was significantly associated with lymph node metastasis and peritoneal metastasis outside the pelvis. There was a significant correlation between the high levels of VEGF-C and VEGF-D proteins, and poor survival. The presence of VEGF-D was an independent prognostic indicator by multivariate analysis. We conclude that VEGF-C, VEGF-D and VEGFR-3 play an important role in lymphatic spread and intraperitoneal tumour development in ovarian carcinoma. Since VEGF-D was found to be an independent predictor of poor outcome, its measurement, together with other prognostic markers may improve prospective identification of patients with a poor prognosis. .

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Figures

Figure 1
Figure 1
Immunohistochemical staining of VEGF-D in ovarian tumours and positive control. (A) Positive control in placental vessel and villi (scale bar, 25 mm). (B) Negative staining in benign cystadenoma (scale bar, 25 mm). (C, D, E, and F) −: negative, ±: weak, +: moderate, ++: strong, respectively, in epithelial ovarian carcinoma tissues (scale bar in C and D: 25 mm, scale bar in E and F: 50 mm). Arrows in F show VEGF-D-positive lymphatic and vascular endothelia adjacent to the carcinoma.
Figure 2
Figure 2
Immunohistochemical staining of VEGFR-3 and VEGF-D in endothelial cells adjacent to carcinoma. (A) VEGFR-3-positive lymphatic and vascular endothelial cells (scale bar, 25 mm). (B) VEGFR-3 staining highlighted vessel invasion by carcinoma cells (arrows) (scale bar, 25 mm). VEGF-D-positive endothelial cells (C) in vessels invaded by ovarian carcinoma was positive for VEGFR-3 (D) (scale bars 25 mm). Arrows on each inset show endothelia that were positive for VEGF-D (C) or VEGFR-3 (D). Asterisks on each inset reveal carcinoma cell (scale bars on inset, 12.5 mm).
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