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Review
. 2002 Jan;2(1):48-58.
doi: 10.1038/nrc706.

Multidrug resistance in cancer: role of ATP-dependent transporters

Michael M Gottesman  1 , Tito Fojo, Susan E Bates
Affiliations
Review

Multidrug resistance in cancer: role of ATP-dependent transporters

Michael M Gottesman et al. Nat Rev Cancer. 2002 Jan.

V体育ios版 - Abstract

Chemotherapeutics are the most effective treatment for metastatic tumours VSports手机版. However, the ability of cancer cells to become simultaneously resistant to different drugs--a trait known as multidrug resistance--remains a significant impediment to successful chemotherapy. Three decades of multidrug-resistance research have identified a myriad of ways in which cancer cells can elude chemotherapy, and it has become apparent that resistance exists against every effective drug, even our newest agents. Therefore, the ability to predict and circumvent drug resistance is likely to improve chemotherapy. .

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