"V体育2025版" Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The . gov means it’s official. Federal government websites often end in . gov or . mil. Before sharing sensitive information, make sure you’re on a federal government site. VSports app下载.

Https

The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely V体育官网. .

. 2001 May 15;166(10):5909-16.
doi: 10.4049/jimmunol.166.10.5909.

Requirement for leptin in the induction and progression of autoimmune encephalomyelitis

G Matarese  1 , A Di Giacomo, V Sanna, G M Lord, J K Howard, A Di Tuoro, S R Bloom, R I Lechler, S Zappacosta, S Fontana
Affiliations

V体育官网入口 - Requirement for leptin in the induction and progression of autoimmune encephalomyelitis

G Matarese et al. J Immunol. .

Abstract

Recent evidence indicates that leptin modifies T cell immunity, and may provide a key link between nutritional deficiency and immune dysfunction VSports手机版. To study the influence of leptin on autoimmunity, susceptibility to experimental autoimmune encephalomyelitis induced by immunization with a myelin-derived peptide was examined in leptin-deficient, C57BL/6J-ob/ob mice, with or without leptin replacement, and in wild-type controls. Leptin replacement converted disease resistance to susceptibility in the C57BL/6J-ob/ob mice; this was accompanied by a switch from a Th2 to Th1 pattern of cytokine release and consequent reversal of Ig subclass production. Our findings suggest that leptin is required for the induction and maintenance of an effective proinflammatory immune response in the CNS. .

PubMed Disclaimer

Publication types

MeSH terms (VSports)

LinkOut - more resources