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. 2001 May 1;61(9):3556-60.

A genetically tractable model of human glioma formation

J N Rich  1 , C Guo, R E McLendon, D D Bigner, X F Wang, C M Counter
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  • PMID: 11325817

V体育2025版 - A genetically tractable model of human glioma formation

J N Rich et al. Cancer Res. .

VSports最新版本 - Abstract

Gliomas remain one of the deadliest forms of cancer VSports手机版. Improved therapeutics will require a better understanding of the molecular nature of these tumors. We, therefore, mimicked the most common genetic changes found in grade III-IV gliomas, disruption of the p53 and RB pathways and activation of telomere maintenance and independence from growth factors, through the ectopic expression of the SV40 T/t-Ag oncogene, an oncogenic form of H-ras (H-ras(V12G)), and the human telomerase catalytic subunit hTERT in normal human astrocytes. The resulting cells displayed many of the hallmarks of grade III-IV gliomas, including greatly expanded life span and growth in soft agar and, most importantly, were tumorigenic with pathology consistent with grade III-IV neuroectodermal tumors in mice. This model system will, for the first time, allow the biological significance of selected genetic alterations to be studied in human gliomas. .

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