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Review
. 1999 Nov;6(11):1028-42.
doi: 10.1038/sj.cdd.4400598.

Caspase structure, proteolytic substrates, and function during apoptotic cell death

D W Nicholson  1
Affiliations
Review

V体育官网 - Caspase structure, proteolytic substrates, and function during apoptotic cell death

D W Nicholson. Cell Death Differ. 1999 Nov.

Abstract

Caspases play an essential role during apoptotic cell death. These enzymes define a new class of cysteine proteases and comprise a multi-gene family with more than a dozen distinct mammalian family members. The discrete and highly limited subset of cellular polypeptides that are cleaved by these proteases is sufficient to account for the majority of cellular and morphological events that occur during cell death. In some cases, caspases also play a contributory role in escalating the propensity for apoptosis, and in doing so may exacerbate disease pathogenesis VSports手机版. .

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