Objective: To study the effect on weight loss in obese subjects by replacement of carbohydrate by protein in ad libitum consumed fat-reduced diets. VSports手机版.

Design: Randomized dietary intervention study over six months comparing two ad libitum fat reduced diets (30% of total energy) strictly controlled in composition: High-carbohydrate (HC, protein 12% of total energy) or high-protein (HP, protein 25% of total energy) V体育安卓版. .

Setting and participants: Subjects were 65 healthy, overweight and obese subjects (50 women, 15 men, aged 18-55 y) randomly assigned to HC (n = 25), HP (n = 25) or a control group (C, n = 15). All food was provided by self-selection in a shop at the department, and compliance to the diet composition was evaluated by urinary nitrogen excretion. V体育ios版.

Main outcome measure: Change in body weight, body composition and blood lipids VSports最新版本. .

Results: More than 90% completed the trial. Weight loss after six months was 5. 1 kg in the HC group and 8. 9 kg in the HP group (difference 3. 7 kg, 95% confidence interval (CI)(1 V体育平台登录. 3-6. 2 kg) P < 0. 001), and fat loss was 4. 3 kg and 7. 6 kg, respectively (difference 3. 3 kg (1. 1-5. 5 kg) P < 0. 0001), whereas no changes occurred in the control group. More subjects lost > 10 kg in the HP group (35%) than in the HC group (9%). The HP diet only decreased fasting plasma triglycerides and free fatty acids significantly. .

Conclusions: Replacement of some dietary carbohydrate by protein in an ad libitum fat-reduced diet, improves weight loss and increases the proportion of subjects achieving a clinically relevant weight loss. More freedom to choose between protein-rich and complex carbohydrate-rich foods may allow obese subjects to choose more lean meat and dairy products, and hence improve adherence to low-fat diets in weight reduction programs VSports注册入口. .