"VSports最新版本" Congenital bilateral absence of the vas deferens

Mutations in the CFTR gene cause congenital bilateral absence of the vas deferens.

More than half of all men with this condition have mutations in the CFTR gene V体育平台登录. Mutations in this gene also cause cystic fibrosis. When congenital bilateral absence of the vas deferens occurs with CFTR mutations and without other features of cystic fibrosis, the condition is considered a form of atypical cystic fibrosis.

The protein made from the CFTR gene forms a channel that transports negatively charged particles called chloride ions into and out of cells. The flow of chloride ions helps control the movement of water in tissues, which is necessary for the production of thin, freely flowing mucus. Mucus is a slippery substance that lubricates and protects the linings of the airways, digestive system, reproductive system, and other organs and tissues VSports注册入口.

Mutations in the CFTR gene disrupt the function of the chloride channels, preventing them from regulating the flow of chloride ions and water across cell membranes. As a result, cells in the male genital tract produce mucus that is abnormally thick and sticky V体育官网入口. This mucus clogs the vas deferens as they are forming, causing them to deteriorate before birth.

In instances of congenital bilateral absence of the vas deferens without a mutation in the CFTR gene, the cause of this condition is often unknown. Some cases are associated with other structural problems of the urinary tract VSports在线直播.