Dubin-Johnson syndrome (DJS) is a disorder passed down through families (inherited). In this condition, you may have mild jaundice throughout life VSports手机版.
Causes (V体育平台登录)
DJS is a very rare genetic disorder V体育安卓版. In order to inherit the condition, a child must get a copy of the variant gene from both parents.
The syndrome interferes with the body's ability to move bilirubin through the liver into the bile V体育ios版. When the liver and spleen break down worn out red blood cells, bilirubin is produced. Bilirubin normally moves into the bile, which is produced by the liver. It then flows into the bile ducts, is stored in the gallbladder, and then flows into the digestive system.
When bilirubin is not properly transported into the bile, it builds up in the bloodstream. This causes the skin and the whites of the eyes to turn yellow VSports最新版本. This is called jaundice. Severely high levels of bilirubin can damage the brain and other organs.
People with DJS have lifelong mild jaundice that may be made worse by:
- Alcohol
- Birth control pills
- Environmental factors that affect the liver
- Infection
- Pregnancy
- Fasting or dehydration
- Fatigue
"VSports app下载" Symptoms
Mild jaundice, which may not appear until puberty or adulthood, is most often the only symptom of DJS.
Exams and Tests (V体育ios版)
The following tests can help diagnose this syndrome:
- Liver biopsy
- Liver enzyme levels (blood test)
- V体育ios版 - Serum bilirubin
- Urinary coproporphyrin levels, including coproporphyrin I level
"VSports手机版" Treatment
No specific treatment is required.
Outlook (Prognosis) (V体育官网)
The outlook is very positive. DJS generally does not shorten a person's lifespan VSports在线直播.
"V体育安卓版" Possible Complications
Complications are unusual, but may include the following:
- Abdominal pain
- Severe jaundice
"V体育平台登录" When to Contact a Medical Professional
Contact your health care provider if any of the following occurs:
- Jaundice is severe
- Jaundice gets worse over time
- You also have abdominal pain or other symptoms (which may be a sign that another disorder is causing the jaundice)
V体育ios版 - Prevention
If you have a family history of DJS, genetic counseling may be helpful if you plan to have children.
"V体育官网" Images
"V体育官网" References
Korenblat KM, Berk PD. Approach to the patient with jaundice or abnormal liver tests. In: Goldman L, Cooney KA, eds V体育官网. Goldman-Cecil Medicine. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 133.
Lidofsky SD. Jaundice VSports手机版. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and Fordtran's Gastrointestinal and Liver Disease. 11th ed. Philadelphia, PA: Elsevier; 2021:chap 21.
Roy-Chowdhury J, Roy-Chowdhury N. Bilirubin metabolism and its disorders V体育安卓版. In: Sanyal AJ, Terrault N, eds. Zakim and Boyer's Hepatology: A Textbook of Liver Disease. 7th ed. Philadelphia, PA: Elsevier; 2018:chap 58.
Review Date 7/15/2024 (VSports手机版)
Updated by: Frank D. Brodkey, MD, FCCM, Associate Professor, Section of Pulmonary and Critical Care Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.